Pharmacogenomics in drug development: societal and technical aspects
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چکیده
منابع مشابه
personalized medicine: pharmacogenomics and drug development
personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...
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Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced by many different genes. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patients' genotype, to maximize efficacy with minimal adverse drug reactions. Pharma...
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Now that all 30,000 or so genes that make up the human genome have been deciphered, pharmaceutical industries are emerging to capitalize the custom based drug treatment. Understanding human genetic variation promises to have a great impact on our ability to uncover the cause of individual variation in response to therapeutics. The study of association between genetics and drug response is calle...
متن کاملRole of pharmacogenomics in the drug development.
Individuals respond differently to drugs and sometimes the effects are unpredictable. Differences in DNA that alter the expression or function of proteins targeted by drugs can contribute significantly to the variation in the individuals responses. The use of pharmacogenomics is to identify genetic polymorphisms that predispose patients to adverse drug effects that, although they may occur in o...
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Effect of a drug is not always uniform throughout the human population. Drugs working well in one patient population may not work well in another population. Furthermore, some drugs may show adverse reactions with or without intended effects. Some drugs may even fail to exert any effect. Such unpredictable drug effects are due to a generalized approach iadopted for drug development. Today's dru...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2004
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500249